Drug Efficacy

A detailed understanding of in-vivo molecular response to a pharmacological agent is key to assessing whether the candidate drug is modulating the intended target and target pathways. At BG Medicine, this not only involves evaluation of changes within individual molecules in the vicinity of the target, but also the assessment of the integrated measurement set comprising diverse analyte types which reflect the underlying systemic biochemical response to drug perturbation. By correlating these changes to desirable outcomes, and interpreting observations with sophisticated bioinformatics capabilities, an integrated molecular landscape is elucidated.

Longitudinal Analysis of Drug Efficacy

• Concentration of an endogenous plasma metabolite followed during the course of 16 weeks of treatment. A less efficacious intervention (red symbols) proved unable to control the level of this important disease-related molecule, while a different dosage (green) prevented dysregulation out to 16 weeks.
  

Correlation Network™ Analysis of Target Pathway Modulation

• Top panel (A) and bottom panel (B) represent the measured changes in analyte levels as well as analyte correlations in two different drug/disease states from two in vivo studies. These networks comprise lipids, proteins, other endogenous metabolites and gene transcripts- representing an integrated analysis- and the empirically measured correlations among them (represented as red or green connections; p<0.01). The efficacy of these two drug interventions on these key biochemical pathways is measured to be statistically significantly different across multiple biochemical regions.