Disease Mechanisms

Understanding molecular pathophysiology at a detailed level of individual proteins, endogenous metabolites and nucleic acids enables a precise determination of functional disease effects. Whether related to novel compounds, molecular targets or distinct clinical phenotypes, characterization of the ‘molecular phenotypes’ of disease is fundamental to better and more efficient research and development.

Illuminating disease at a molecular pathophysiology level enhances therapeutic area expertise across discovery and development processes, including:

• Preclinical model selection.
• Combination product opportunities.
• Target pathway interactions.
• Disease biomarkers.

Molecular Phenotypes of Disease

• A representation of over 200 lipids, proteins and other analytes revealing three distinct molecular phenotypes

Disease Biomarkers

• Performance from a plasma multivariate index assay correlated with imaging assessment of disease. Each data point represents an individual human patient, and the Index Score of that patient based upon plasma analytes. Cross-validated sensitivity and specificity are greater than 85% each, with a p-value < 0.001.